PMID:9851048

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Citation

Patte, JC, Akrim, M and Méjean, V (1998) The leader sequence of the Escherichia coli lysC gene is involved in the regulation of LysC synthesis. FEMS Microbiol. Lett. 169:165-70

Abstract

In Escherichia coli and Bacillus subtilis, long leader sequences are found upstream of the lysC coding sequences which encode lysine-sensitive aspartokinase. Highly conserved regions exist between these sequences. Mutations leading to constitutive expression of the E. coli lysC gene have been localised within these conserved regions, indicating that they participate in the lysine-mediated repression mechanism of lysC expression.

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Keywords

Aspartate Kinase/biosynthesis; Aspartate Kinase/genetics; Base Sequence; Escherichia coli/enzymology; Escherichia coli/genetics; Gene Expression Regulation, Bacterial; Genes, Bacterial; Molecular Sequence Data; Regulatory Sequences, Nucleic Acid; Sequence Homology, Nucleic Acid

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