PMID:9785447

Citation	Visick, JE, Ichikawa, JK and Clarke, S (1998) Mutations in the Escherichia coli surE gene increase isoaspartyl accumulation in a strain lacking the pcm repair methyltransferase but suppress stress-survival phenotypes. FEMS Microbiol. Lett. 167:19-25
Abstract	The Escherichia coli surE gene is co-transcribed with pcm, encoding the L-isoaspartyl protein repair methyltransferase, and is highly conserved among both the Eubacteria and the Archaea; however, no biochemical function has yet been identified for this gene. Isoaspartyl accumulation during stationary phase was much higher in a pcm surE double mutant than in either single mutant, suggesting that the two genes may represent two parallel pathways by which E. coli can respond to protein damage. A null mutation in surE also suppressed stress-survival defects previously observed in a pcm mutant strain, providing further evidence for an interaction between the two gene products.
Links	PubMed
Keywords	Acid Phosphatase; Aspartic Acid/metabolism; Bacterial Proteins/chemistry; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Escherichia coli/genetics; Escherichia coli/growth & development; Escherichia coli/metabolism; Escherichia coli Proteins; Genes, Bacterial; Mutation; Phenotype; Phylogeny; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Protein Methyltransferases/genetics; Protein Methyltransferases/metabolism
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