PMID:9774350

Citation	Altuvia, S, Zhang, A, Argaman, L, Tiwari, A and Storz, G (1998) The Escherichia coli OxyS regulatory RNA represses fhlA translation by blocking ribosome binding. EMBO J. 17:6069-75
Abstract	OxyS is a small untranslated RNA which is induced in response to oxidative stress in Escherichia coli. This novel RNA acts as a global regulator to activate or repress the expression of as many as 40 genes, including the fhlA-encoded transcriptional activator and the rpoS-encoded sigma(s) subunit of RNA polymerase. Deletion analysis of OxyS showed that different domains of the small RNA are required for the regulation of fhlA and rpoS. We examined the mechanism of OxyS repression of fhlA and found that the OxyS RNA inhibits fhlA translation by pairing with a short sequence overlapping the Shine-Dalgarno sequence, thereby blocking ribosome binding/translation.
Links	PubMed PMC1170933 Online version:10.1093/emboj/17.20.6069
Keywords	Base Sequence; Dimerization; Escherichia coli; Escherichia coli Proteins; Molecular Sequence Data; Mutagenesis; Nucleic Acid Conformation; Nucleic Acid Heteroduplexes/metabolism; Oxidative Stress/genetics; RNA, Bacterial/chemistry; RNA, Bacterial/pharmacology; RNA, Bacterial/physiology; Regulatory Sequences, Nucleic Acid/physiology; Ribosomes/genetics; Ribosomes/metabolism; Trans-Activators/antagonists & inhibitors; Trans-Activators/biosynthesis; Trans-Activators/genetics; Untranslated Regions/physiology
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