PMID:9770507

Citation	Lease, RA, Cusick, ME and Belfort, M (1998) Riboregulation in Escherichia coli: DsrA RNA acts by RNA:RNA interactions at multiple loci. Proc. Natl. Acad. Sci. U.S.A. 95:12456-61
Abstract	DsrA is an 87-nt untranslated RNA that regulates both the global transcriptional silencer and nucleoid protein H-NS and the stationary phase and stress response sigma factor RpoS (sigmas). We demonstrate that DsrA acts via specific RNA:RNA base pairing interactions at the hns locus to antagonize H-NS translation. We also give evidence that supports a role for RNA:RNA interactions at the rpoS locus to enhance RpoS translation. Negative regulation of hns by DsrA is achieved by the RNA:RNA interaction blocking translation of hns RNA. In contrast, results suggest that positive regulation of rpoS by DsrA occurs by formation of an RNA structure that activates a cis-acting translational operator. Sequences within DsrA complementary to three additional genes, argR, ilvIH, and rbsD, suggest that DsrA is a riboregulator of gene expression that acts coordinately via RNA:RNA interactions at multiple loci.
Links	PubMed PMC22852
Keywords	Bacterial Proteins/genetics; Base Sequence; DNA Primers; DNA-Binding Proteins/genetics; Escherichia coli/genetics; Genes, Bacterial; Nucleic Acid Conformation; Protein Biosynthesis; RNA, Bacterial/chemistry; RNA, Bacterial/metabolism; Sigma Factor/genetics
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