PMID:9666469
| Citation |
Kang, HY, Song, S and Park, C (1998) Priority of pentose utilization at the level of transcription: arabinose, xylose, and ribose operons. Mol. Cells 8:318-23 |
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| Abstract |
When E. coli cells were grown in minimal medium supplemented with D-ribose and D-xylose, a diauxic growth preferring D-xylose was observed. Transcription of the ribose (rbs) operon was repressed in the presence of D-xylose, phenotypically similar to catabolite repression by D-glucose, although D-ribose did not affect transcription of the xylose (xyl) operon. Complementation analysis with xylR revealed that the repression of the rbs operon by D-xylose is exerted at the transcriptional level through XylR, suggesting a novel mechanism for catabolite repression. Furthermore, it was shown that L-arabinose reduced transcriptions of both xyl and rbs operons, whereas the arabinose operon was not affected by D-xylose or D-ribose, suggesting a priority mechanism for pentose utilization. |
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| Keywords |
Arabinose/genetics; Arabinose/pharmacology; Bacterial Proteins; Cell Division/drug effects; DNA-Binding Proteins/genetics; Escherichia coli/drug effects; Escherichia coli/genetics; Escherichia coli/metabolism; Gene Expression Regulation, Bacterial/drug effects; Gene Expression Regulation, Bacterial/genetics; Genes, Bacterial/drug effects; Genes, Bacterial/genetics; Operon/drug effects; Operon/genetics; Operon/physiology; Pentoses/metabolism; Pentoses/pharmacology; Repressor Proteins/genetics; Ribose/genetics; Ribose/pharmacology; Transcription Factors/genetics; Transcription, Genetic/drug effects; Transcription, Genetic/genetics; Xylose/genetics; Xylose/pharmacology |
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