PMID:9653517
| Citation |
Suenaga, A, Komeiji, Y, Uebayasi, M, Meguro, T, Saito, M and Yamato, I (1998) Computational observation of an ion permeation through a channel protein. Biosci. Rep. 18:39-48 |
|---|---|
| Abstract |
The ion permeation process, driven by a membrane potential through an outer membrane protein, OmpF porin of Escherichia coli, was simulated by molecular dynamics. A Na+ ion, initially placed in the solvent region at the outer side of the porin channel, moved along the electric field passing through the porin channel in a 1.3 nsec simulation; the permeation rate was consistent with the experimentally estimated channel activity (10(8)-10(9)/sec). It this simulation, it was indicated that the ion permeation through the porin channel proceeds by a "push-out" mechanism, and that Asp113 is an important residue for the channel activity. |
| Links | |
| Keywords |
Bacterial Proteins/metabolism; Computer Simulation; Ion Transport; Models, Molecular; Porins/metabolism |
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