PMID:9653451
| Citation |
Asad, NR, Asad, LM, Silva, AB, Felzenszwalb, I and Leitão, AC (1998) Hydrogen peroxide induces protection against lethal effects of cumene hydroperoxide in Escherichia coli cells: an Ahp dependent and OxyR independent system? Mutat. Res. 407:253-9 |
|---|---|
| Abstract |
Pretreatment with 2.5 mM H2O2 protects bacterial cells against cumene hydroperoxide killing. This response is independent of the OxyR system, but possibly involves the participation of Ahp protein, since ahp mutants are not protected. Treatment of bacterial cells with high H2O2 concentrations caused an alteration on the electrophoretic profile of the smaller subunit (22-kDa) of Ahp. This alteration does not require novel gene products and is not dependent on the OxyR protein. In this way, we propose that the modification of the 22-kDa subunit of Ahp by high H2O2 concentration may be responsible for the protection against the lethal effects of cumene hydroperoxide. |
| Links | |
| Keywords |
Bacterial Proteins/physiology; Benzene Derivatives/toxicity; DNA-Binding Proteins; Drug Antagonism; Escherichia coli/drug effects; Escherichia coli/physiology; Escherichia coli Proteins; Hydrogen Peroxide/pharmacology; Oxidants/toxicity; Oxidoreductases/physiology; Peroxidases; Peroxiredoxins; Repressor Proteins/physiology; Transcription Factors/physiology |
| edit table |
Significance
You can help EcoliWiki by summarizing why this paper is useful
Useful Materials and Methods
You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.
Annotations
<annotationlinks/>
EcoliWiki Links
Add links to pages that link here (e.g. gene, product, method pages)
References
See Help:References for how to manage references in EcoliWiki.