PMID:9642209
| Citation |
Pogliano, J, Dong, JM, De Wulf, P, Furlong, D, Boyd, D, Losick, R, Pogliano, K and Lin, EC (1998) Aberrant cell division and random FtsZ ring positioning in Escherichia coli cpxA* mutants. J. Bacteriol. 180:3486-90 |
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| Abstract |
In Escherichia coli, certain mutations in the cpxA gene (encoding a sensor kinase of a two-component signal transduction system) randomize the location of FtsZ ring assembly and dramatically affect cell division. However, deletion of the cpxRA operon, encoding the sensor kinase and its cognate regulator CpxR, has no effect on division site biogenesis. It appears that certain mutant sensor kinases (CpxA*) either exhibit hyperactivity on CpxR or extend their signalling activity to one or more noncognate response regulators involved in cell division. |
| Links | |
| Keywords |
Bacterial Proteins/analysis; Bacterial Proteins/biosynthesis; Cell Division; Chromosome Deletion; Chromosomes, Bacterial; Cytoskeletal Proteins; Escherichia coli/cytology; Escherichia coli/genetics; Escherichia coli/ultrastructure; Escherichia coli Proteins; GTP-Binding Proteins/biosynthesis; Genotype; Microscopy, Electron; Operon; Protein Kinases/genetics; Signal Transduction |
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