PMID:9634230
| Citation |
Cole, ST, Brosch, R, Parkhill, J, Garnier, T, Churcher, C, Harris, D, Gordon, SV, Eiglmeier, K, Gas, S, Barry, CE 3rd, Tekaia, F, Badcock, K, Basham, D, Brown, D, Chillingworth, T, Connor, R, Davies, R, Devlin, K, Feltwell, T, Gentles, S, Hamlin, N, Holroyd, S, Hornsby, T, Jagels, K, Krogh, A, McLean, J, Moule, S, Murphy, L, Oliver, K, Osborne, J, Quail, MA, Rajandream, MA, Rogers, J, Rutter, S, Seeger, K, Skelton, J, Squares, R, Squares, S, Sulston, JE, Taylor, K, Whitehead, S and Barrell, BG (1998) Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393:537-44 |
|---|---|
| Abstract |
Countless millions of people have died from tuberculosis, a chronic infectious disease caused by the tubercle bacillus. The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to improve our understanding of the biology of this slow-growing pathogen and to help the conception of new prophylactic and therapeutic interventions. The genome comprises 4,411,529 base pairs, contains around 4,000 genes, and has a very high guanine + cytosine content that is reflected in the biased amino-acid content of the proteins. M. tuberculosis differs radically from other bacteria in that a very large portion of its coding capacity is devoted to the production of enzymes involved in lipogenesis and lipolysis, and to two new families of glycine-rich proteins with a repetitive structure that may represent a source of antigenic variation. |
| Links |
PubMed Online version:10.1038/31159 |
| Keywords |
Chromosome Mapping; Chromosomes, Bacterial; Drug Resistance, Microbial; Genome, Bacterial; Humans; Lipid Metabolism; Molecular Sequence Data; Mycobacterium tuberculosis/genetics; Mycobacterium tuberculosis/immunology; Mycobacterium tuberculosis/metabolism; Mycobacterium tuberculosis/pathogenicity; Sequence Analysis, DNA; Tuberculosis/microbiology |
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