PMID:9573164
| Citation |
King, SC and Li, S (1998) Suppressor scanning at positions 177 and 236 in the Escherichia coli lactose/H+ cotransporter and stereotypical effects of acidic substituents that suggest a favored orientation of transmembrane segments relative to the lipid bilayer. J. Bacteriol. 180:2756-8 |
|---|---|
| Abstract |
Acidic substituents for Ala-177 (helix 6) or Tyr-236 (helix 7) in LacY cause effects on sugar recognition and cosubstrate coupling that are stereotypical of neutral substituents. Thus, helices 6 and 7 are probably oriented to produce little side-chain contact with the low dielectric lipid bilayer at positions 177 and 236. |
| Links | |
| Keywords |
Carrier Proteins/chemistry; Escherichia coli/enzymology; Escherichia coli Proteins; Lipid Bilayers/chemistry; Membrane Transport Proteins/chemistry; Membrane Transport Proteins/genetics; Monosaccharide Transport Proteins; Protein Conformation; Symporters |
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