PMID:9565753
| Citation |
Hillier, BJ, Rodriguez, HM and Gregoret, LM (1998) Coupling protein stability and protein function in Escherichia coli CspA. Fold Des 3:87-93 |
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| Abstract |
CspA is a small protein that binds single-stranded RNA and DNA. The binding site of CspA consists of a cluster of aromatic amino acids, which form an unusually large nonpolar patch on the surface of the protein. Because nonpolar residues are generally found in the interiors of proteins, this cluster may have evolved to bind nucleic acids at the expense of protein stability. |
| Links | |
| Keywords |
Bacterial Proteins; Binding Sites/genetics; Circular Dichroism; DNA, Single-Stranded/metabolism; DNA-Binding Proteins/chemistry; Escherichia coli/metabolism; Heat-Shock Proteins/chemistry; Heat-Shock Proteins/genetics; Models, Molecular; Mutagenesis, Insertional/genetics; Protein Denaturation; Protein Structure, Secondary; RNA-Binding Proteins/chemistry; RNA-Binding Proteins/genetics; Urea/pharmacology |
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