PMID:9562556
| Citation |
Gallagher, DT, Gilliland, GL, Xiao, G, Zondlo, J, Fisher, KE, Chinchilla, D and Eisenstein, E (1998) Structure and control of pyridoxal phosphate dependent allosteric threonine deaminase. Structure 6:465-75 |
|---|---|
| Abstract |
Feedback inhibition of biosynthetic threonine deaminase (TD) from Escherichia coli provided one of the earliest examples of protein-based metabolic regulation. Isoleucine, the pathway end-product, and valine, the product of a parallel pathway, serve as allosteric inhibitor and activator, respectively. This enzyme is thus a useful model system for studying the structural basis of allosteric control mechanisms. |
| Links | |
| Keywords |
Allosteric Regulation/physiology; Binding Sites/physiology; Carbohydrate Dehydrogenases/chemistry; Crystallography, X-Ray; Dimerization; Enzyme Activation/physiology; Enzyme Inhibitors/pharmacology; Escherichia coli/enzymology; Hydrogen Bonding; Models, Molecular; Phosphoglycerate Dehydrogenase; Protein Conformation; Protein Structure, Secondary; Pyridoxal Phosphate/chemistry; Structure-Activity Relationship; Threonine Dehydratase/chemistry; Tryptophan Synthase/chemistry; Valine/pharmacology |
| edit table |
Significance
You can help EcoliWiki by summarizing why this paper is useful
Useful Materials and Methods
You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.
Annotations
<annotationlinks/>
EcoliWiki Links
Add links to pages that link here (e.g. gene, product, method pages)
References
See Help:References for how to manage references in EcoliWiki.