PMID:9537396
| Citation |
Foster, PL and Rosche, WA (1998) Levels of the Vsr endonuclease do not regulate stationary-phase reversion of a Lac- frameshift allele in Escherichia coli. J. Bacteriol. 180:1944-6 |
|---|---|
| Abstract |
Vsr endonuclease, which initiates very short patch repair, has been hypothesized to regulate mutation in stationary-phase cells. Overexpression of Vsr does dramatically increase the stationary-phase reversion of a Lac- frameshift allele, but the absence of Vsr has no effect. Thus, at least in this case, Vsr has no regulatory role in stationary-phase mutation, and the effects of Vsr overproduction are likely to be artifactual. |
| Links | |
| Keywords |
Alleles; DNA Repair; Endodeoxyribonucleases/physiology; Escherichia coli/genetics; Frameshift Mutation; Lac Operon |
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