PMID:9428651

Citation	Steffensen, SA, Poulsen, AB, Mortensen, KK and Sperling-Petersen, HU (1997) E. coli translation initiation factor IF2--an extremely conserved protein. Comparative sequence analysis of the infB gene in clinical isolates of E. coli. FEBS Lett. 419:281-4
Abstract	The functionally uncharacterised N-terminal of translation initiation factor IF2 has been found to be extremely variable when comparing different bacterial species. In order to study the intraspecies variability of IF2 the 2670 basepairs nucleotide sequence of the infB gene (encoding IF2) was determined in 10 clinical isolates of E. coli. The N-terminal domains (I, II and III) were completely conserved indicating a specific function of this region of IF2. Only one polymorphic position was found in the deduced 890 amino acid sequence. This Gln/Gly490 is located within the central GTP/GDP-binding domain IV of IF2. The results are further evidence that IF2 from E. coli has reached a highly defined level of structural and functional development.
Links	PubMed
Keywords	Conserved Sequence; Escherichia coli/genetics; Genes, Bacterial; Peptide Initiation Factors/genetics; Polymorphism, Genetic; Prokaryotic Initiation Factor-2
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