PMID:9384533
| Citation |
Lin, CH, Chen, S, Kwon, DS, Coward, JK and Walsh, CT (1997) Aldehyde and phosphinate analogs of glutathione and glutathionylspermidine: potent, selective binding inhibitors of the E. coli bifunctional glutathionylspermidine synthetase/amidase. Chem. Biol. 4:859-66 |
|---|---|
| Abstract |
The tripeptide glutathione is converted to glutathionylspermidine (Gsp) in Escherichia coli and in trypanosomatid parasites by an ATP-cleaving Gsp synthetase activity. In parasites, an additional glutathionylation forms bis-(glutathionyl)-spermidine, trypanothione, believed to be the major surveillance thiol involved in oxidant defense mechanisms in trypanosomatid parasites. In E. coli, the Gsp synthetase is part of a bifunctional enzyme opposed by the hydrolytic Gsp amidase. |
| Links | |
| Keywords |
Aldehydes; Amide Synthases/antagonists & inhibitors; Binding Sites; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/metabolism; Escherichia coli/enzymology; Glutathione/analogs & derivatives; Glutathione/chemistry; Models, Chemical; Phosphinic Acids/chemistry; Spermidine/analogs & derivatives; Spermidine/chemistry |
| edit table |
Significance
You can help EcoliWiki by summarizing why this paper is useful
Useful Materials and Methods
You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.
Annotations
<annotationlinks/>
EcoliWiki Links
Add links to pages that link here (e.g. gene, product, method pages)
References
See Help:References for how to manage references in EcoliWiki.
