PMID:9383406

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Citation

Scanlan, TS and Reid, RC (1995) Evolution in action. Chem. Biol. 2:71-5

Abstract

The alpha/beta barrel enzyme phosphotriesterase from soil bacteria appears to have evolved the ability to hydrolyze the insecticide paraoxon at the diffusion limit in only a few decades. A newly-identified open reading frame from Escherichia coli may offer a clue to its origins.

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Keywords

Amino Acid Sequence; Aryldialkylphosphatase; Bacteria/enzymology; Bacteria/genetics; Biological Evolution; Escherichia coli/genetics; Escherichia coli/metabolism; Esterases/biosynthesis; Esterases/chemistry; Esterases/genetics; Insecticides/metabolism; Molecular Sequence Data; Open Reading Frames; Paraoxon/metabolism; Soil Microbiology

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