PMID:9353747
| Citation |
Marshall, NJ and Piddock, LJ (1997) Antibacterial efflux systems. Microbiologia 13:285-300 |
|---|---|
| Abstract |
Drug efflux, unidirectional pumping of cytotoxic drugs, is a major mechanism of antimicrobial multiresistance in bacteria. Although these efflux systems are usually chromosomally encoded, some are present on plasmids. Some of the efflux pumps are relatively well known: Emr and Acr system in Escherichia coli, whose outer membrane protein seems to be the multifunctional To1C; the mex efflux system described in Pseudomonas aeruginosa and ABC-type in Gram-negative bacteria. Also the role of efflux in Gram-positive bacteria are reviewed including Bacillus, Staphylococcus and Streptomyces. |
| Links | |
| Keywords |
ATP-Binding Cassette Transporters/genetics; ATP-Binding Cassette Transporters/physiology; Bacterial Proteins/genetics; Bacterial Proteins/physiology; Biological Transport, Active; Carrier Proteins/genetics; Carrier Proteins/physiology; Chromosomes, Bacterial/genetics; Drug Resistance, Microbial/genetics; Drug Resistance, Microbial/physiology; Drug Resistance, Multiple/genetics; Drug Resistance, Multiple/physiology; Escherichia coli/drug effects; Escherichia coli/genetics; Escherichia coli/physiology; Gram-Negative Bacteria/drug effects; Gram-Negative Bacteria/physiology; Multigene Family; Pseudomonas aeruginosa/drug effects; Pseudomonas aeruginosa/genetics; Pseudomonas aeruginosa/physiology; R Factors/genetics; Tetracycline Resistance/genetics |
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