PMID:9345765
| Citation |
Phoenix, DA and Korotkov, E (1997) Evidence of rare codon clusters within Escherichia coli coding regions. FEMS Microbiol. Lett. 155:63-6 |
|---|---|
| Abstract |
It is known that there is a high occurrence of rare codons at the start of coding region. Here it is shown that although the remainder of the gene is likely to contain a relatively low number of rare codons, rare and non-rare codons do not form a random sequence. It is apparent that throughout the coding region there is a higher than expected number of rare codon clusters. For example once a rare codon has occurred there is a greater chance than expected of the next six codons containing another rare codon. This non-random distribution implies that rare codons may have an as yet unidentified biological role. |
| Links | |
| Keywords |
Base Sequence; Codon/genetics; DNA, Bacterial/genetics; Databases, Factual; Escherichia coli/genetics; Genes, Bacterial; Protein Biosynthesis; Protein Folding |
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