PMID:9311138
| Citation |
Fuentes, AM and Amábile-Cuevas, CF (1997) Mercury induces multiple antibiotic resistance in Escherichia coli through activation of SoxR, a redox-sensing regulatory protein. FEMS Microbiol. Lett. 154:385-8 |
|---|---|
| Abstract |
Sub-inhibitory mercury concentrations are capable of partially activating SoxR, as shown by the augmented expression of a soxS'::lacZ fusion, and a diminished sensitivity to antibiotics caused by mercury treatment. Mercury may elevate the intracellular concentration of superoxide or perhaps act as a putative metal ligand for SoxR. |
| Links | |
| Keywords |
Bacterial Proteins/physiology; Drug Resistance, Microbial; Drug Resistance, Multiple; Escherichia coli/drug effects; Mercury/pharmacology; Transcription Factors/physiology |
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