PMID:9294889

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Citation

Groisman, EA and Ochman, H (1997) How Salmonella became a pathogen. Trends Microbiol. 5:343-9

Abstract

In many pathogens, virulence can be conferred by a single region of the genome. In contrast, the facultative intracellular lifestyle of Salmonella demands a large number of genes distributed around the chromosome. The evolution of Salmonella has been marked by the acquisition of several 'pathogenicity islands', each contributing to the unique virulence properties of this microorganism.

Links

PubMed Online version:10.1016/S0966-842X(97)01099-8

Keywords

Chromosome Mapping; Gene Expression Regulation, Bacterial; Genes, Bacterial/physiology; Gram-Negative Bacteria/genetics; Host-Parasite Interactions/physiology; Phylogeny; Salmonella/genetics; Salmonella/pathogenicity; Salmonella/ultrastructure; Virulence/genetics

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