PMID:9263411
| Citation |
Tse-Dinh, YC, Qi, H and Menzel, R (1997) DNA supercoiling and bacterial adaptation: thermotolerance and thermoresistance. Trends Microbiol. 5:323-6 |
|---|---|
| Abstract |
When bacterial cells are shifted to higher temperatures their degree of DNA supercoiling changes. Topoisomerases are involved in bacterial adaptation to environmental changes requiring rapid shifts in gene expression. This role in heat shock has been elucidated by genetic studies on the Escherichia coli topA gene and its sigma 32-dependent promoter, P1. Other studies have shown that certain gyrA mutants have increased thermoresistance. |
| Links | |
| Keywords |
Adaptation, Physiological; Bacteria/chemistry; Bacteria/genetics; Bacterial Physiological Phenomena; DNA Gyrase; DNA Topoisomerases, Type II/genetics; DNA Topoisomerases, Type II/metabolism; DNA, Bacterial/chemistry; DNA, Superhelical/chemistry; Escherichia coli/chemistry; Escherichia coli/genetics; Escherichia coli/physiology; Genes, Bacterial; Promoter Regions, Genetic; Temperature |
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