PMID:9252185
| Citation |
Tomb, JF, White, O, Kerlavage, AR, Clayton, RA, Sutton, GG, Fleischmann, RD, Ketchum, KA, Klenk, HP, Gill, S, Dougherty, BA, Nelson, K, Quackenbush, J, Zhou, L, Kirkness, EF, Peterson, S, Loftus, B, Richardson, D, Dodson, R, Khalak, HG, Glodek, A, McKenney, K, Fitzegerald, LM, Lee, N, Adams, MD, Hickey, EK, Berg, DE, Gocayne, JD, Utterback, TR, Peterson, JD, Kelley, JM, Cotton, MD, Weidman, JM, Fujii, C, Bowman, C, Watthey, L, Wallin, E, Hayes, WS, Borodovsky, M, Karp, PD, Smith, HO, Fraser, CM and Venter, JC (1997) The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature 388:539-47 |
|---|---|
| Abstract |
Helicobacter pylori, strain 26695, has a circular genome of 1,667,867 base pairs and 1,590 predicted coding sequences. Sequence analysis indicates that H. pylori has well-developed systems for motility, for scavenging iron, and for DNA restriction and modification. Many putative adhesins, lipoproteins and other outer membrane proteins were identified, underscoring the potential complexity of host-pathogen interaction. Based on the large number of sequence-related genes encoding outer membrane proteins and the presence of homopolymeric tracts and dinucleotide repeats in coding sequences, H. pylori, like several other mucosal pathogens, probably uses recombination and slipped-strand mispairing within repeats as mechanisms for antigenic variation and adaptive evolution. Consistent with its restricted niche, H. pylori has a few regulatory networks, and a limited metabolic repertoire and biosynthetic capacity. Its survival in acid conditions depends, in part, on its ability to establish a positive inside-membrane potential in low pH. |
| Links |
PubMed Online version:10.1038/41483 |
| Keywords |
Antigenic Variation; Bacterial Adhesion; Bacterial Proteins/secretion; Base Sequence; Biological Evolution; Cell Division; DNA Repair; DNA, Bacterial/genetics; Gene Expression Regulation, Bacterial; Genome, Bacterial; Helicobacter pylori/genetics; Helicobacter pylori/metabolism; Helicobacter pylori/pathogenicity; Hydrogen-Ion Concentration; Molecular Sequence Data; Protein Biosynthesis; Recombination, Genetic; Transcription, Genetic; Virulence |
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