PMID:9224870

Citation	Russel, M, Linderoth, NA and Sali, A (1997) Filamentous phage assembly: variation on a protein export theme. Gene 192:23-32
Abstract	Biogenesis of both filamentous phage and type-IV pili involves the assembly of many copies of a small, integral inner membrane protein (the phage major coat protein or pilin) into a helical, tubular array that passes through the outer membrane. The occurrence of related proteins required for assembly and export in both systems suggests that there may be similarities at the mechanistic level as well. This report summarizes the properties of filamentous phage and the proteins required for their assembly, with particular emphasis on features they may share with bacterial protein export and pilus biogenesis systems, and it presents evidence that supports the hypothesis that one of the phage proteins functions as an outer membrane export channel.
Links	PubMed
Keywords	Bacterial Outer Membrane Proteins/genetics; Bacterial Outer Membrane Proteins/metabolism; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Bacteriophages/genetics; Bacteriophages/metabolism; Biological Transport/physiology; Fimbriae Proteins; Fimbriae, Bacterial/genetics; Fimbriae, Bacterial/metabolism; Genes, Viral; Protein Conformation; Sequence Alignment; Viral Proteins/metabolism
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