PMID:9204707
| Citation |
Hidalgo, E, Ding, H and Demple, B (1997) Redox signal transduction via iron-sulfur clusters in the SoxR transcription activator. Trends Biochem. Sci. 22:207-10 |
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| Abstract |
Protein iron-sulfur (FeS) centers have recently been implicated in the regulation of gene expression. In the redox-sensing SoxR protein, the oxidation state of [2Fe-2S] centers controls its activity as a transcription activator independent of DNA-binding ability. Thus, FeS centers allosterically link cellular oxidative stress to the expression of defense genes. |
| Links | |
| Keywords |
Bacterial Proteins/chemistry; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Gene Expression Regulation/genetics; Iron-Sulfur Proteins/metabolism; Nitric Oxide/metabolism; Oxidation-Reduction; Promoter Regions, Genetic/genetics; Reactive Oxygen Species/metabolism; Signal Transduction; Transcription Factors/chemistry; Transcription Factors/genetics; Transcription Factors/metabolism; Transcriptional Activation |
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