PMID:9204275
| Citation |
Moore, PB (1997) The conformation of ribosomes and rRNA. Curr. Opin. Struct. Biol. 7:343-7 |
|---|---|
| Abstract |
During the past 18 months, electron microscopists have published two reconstructions of the Escherichia coli ribosome, independently derived from images of unstained particles. The resolutions of their images are 20-25 A-much higher than any previously available. During the same time, NMR spectroscopists have provided an atomic-resolution model for the A-site region of 16S rRNA complexed with paromomycin that explains much of what is known about the interaction of aminoglycoside antibiotics with ribosomes. |
| Links | |
| Keywords |
Microscopy, Electron/methods; Models, Biological; Models, Molecular; Nucleic Acid Conformation; Paromomycin/chemistry; Paromomycin/metabolism; RNA, Ribosomal/chemistry; RNA, Ribosomal/metabolism; RNA, Ribosomal, 16S/chemistry; RNA, Ribosomal, 16S/metabolism; Ribosomes/chemistry; Ribosomes/metabolism |
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