PMID:9202483
| Citation |
Chen, CF, Lan, J, Korovine, M, Shao, ZQ, Tao, L, Zhang, J and Newman, EB (1997) Metabolic regulation of lrp gene expression in Escherichia coli K-12. Microbiology (Reading, Engl.) 143 ( Pt 6):2079-84 |
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| Abstract |
Expression of the lrp gene is regulated in part by the nutrients available to the cell, and is decreased in rich medium, in glucose minimal media enriched with amino acids, and in minimal medium with alternative carbon sources, such as acetate and succinate. When Lrp production is increased in a given medium, expression of its target genes is also increased. However, when the medium is changed from glucose to acetate, the response of the target genes is governed by many factors. |
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| Keywords |
Amino Acids/pharmacology; Bacterial Proteins/genetics; Bacterial Proteins/physiology; Carbon/pharmacology; Culture Media/metabolism; DNA-Binding Proteins/genetics; DNA-Binding Proteins/physiology; Escherichia coli/genetics; Escherichia coli/growth & development; Escherichia coli/metabolism; Escherichia coli Proteins; Gene Expression/drug effects; Gene Expression/genetics; Gene Expression/physiology; Gene Expression Regulation, Bacterial/genetics; Genes, Bacterial/genetics; Genes, Bacterial/physiology; Leucine/physiology; Leucine-Responsive Regulatory Protein; Transcription Factors/genetics; Transcription Factors/physiology |
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