PMID:9179856

Citation	Zgurskaya, HI, Keyhan, M and Matin, A (1997) The sigma S level in starving Escherichia coli cells increases solely as a result of its increased stability, despite decreased synthesis. Mol. Microbiol. 24:643-51
Abstract	The sigma S level in starving (stationary phase) Escherichia coli cells increases four-to sixfold following growth in a defined or a complex medium. Chemostat-grown cells, subjected to increasing carbon starvation, also become progressively richer in sigma S content. These increases occur despite reduced transcription of the sigma S-encoding gene, rpoS, and translation of rpoS mRNA, and result solely from a large increase in the stability of the sigma protein. Previous results, based on rpoS::lacZ transcriptional and translational fusions, and on methionine incorporation in sigma S, had suggested increased synthesis of sigma S in starving cells. Alternative explanations for these results consistent with the conclusions of this paper are discussed.
Links	PubMed
Keywords	Bacterial Proteins/biosynthesis; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Drug Stability; Escherichia coli/genetics; Escherichia coli/growth & development; Escherichia coli/metabolism; Genes, Bacterial; Guanosine Tetraphosphate/metabolism; Interphase; Protein Biosynthesis; RNA, Bacterial/genetics; RNA, Bacterial/metabolism; RNA, Messenger/genetics; RNA, Messenger/metabolism; Sigma Factor/biosynthesis; Sigma Factor/genetics; Sigma Factor/metabolism
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