PMID:9162504
| Citation |
Travers, A (1997) DNA-protein interactions: IHF--the master bender. Curr. Biol. 7:R252-4 |
|---|---|
| Abstract |
The crystal structure of Escherichia coli integration host factor complexed with DNA reveals how the sequence-specificity of DNA binding can be determined almost entirely by the structural features of the DNA itself and not by direct readout of the base sequence. There are lessons to be drawn for other DNA-binding motifs. |
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| Keywords |
Amino Acid Sequence; Animals; Bacterial Proteins/chemistry; Bacterial Proteins/metabolism; Base Sequence; Binding Sites; Conserved Sequence; DNA/chemistry; DNA/metabolism; DNA-Binding Proteins/chemistry; DNA-Binding Proteins/metabolism; Escherichia coli/metabolism; Humans; Integration Host Factors; Macromolecular Substances; Models, Structural; Nucleic Acid Conformation; Protein Structure, Secondary |
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