PMID:9140062
| Citation |
Aki, T, Choy, HE and Adhya, S (1996) Histone-like protein HU as a specific transcriptional regulator: co-factor role in repression of gal transcription by GAL repressor. Genes Cells 1:179-88 |
|---|---|
| Abstract |
Transcription initiation from the two overlapping promoters of the gal operon in Escherichia coli is negatively regulated by binding of Gal repressor (GalR) to bipartite operators, which encompass the promoters. Coordinated repression of the two promoters requires GalR binding to both operators. In a purified system, GalR, nevertheless, fails to show the coordinated repression, predicting the participation of an additional factor(s) in the regulation in vivo. |
| Links | |
| Keywords |
Bacterial Proteins/metabolism; DNA Footprinting; DNA, Superhelical/genetics; DNA, Superhelical/metabolism; DNA-Binding Proteins/metabolism; Escherichia coli/genetics; Escherichia coli Proteins; Galactose/biosynthesis; Gene Expression Regulation, Bacterial; Models, Genetic; Mutation; Nucleic Acid Conformation; Operon/genetics; Repressor Proteins/metabolism; Transcription Factors/metabolism; Transcription, Genetic |
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