PMID:9140059
| Citation |
Sekiguchi, M (1996) MutT-related error avoidance mechanism for DNA synthesis. Genes Cells 1:139-45 |
|---|---|
| Abstract |
Mutator mutants that show an increased frequency of spontaneous mutation have led to the elucidation of the multiple pathways of spontaneous mutagenesis. 8-Oxo-dGTP (8-oxo-7,8-dihydrodeoxyguanosine triphosphate) is formed in the nucleotide pool of a cell during normal cellular metabolism, and when it is incorporated into DNA causes mutation. MutT protein of Escherichia coli and related mammalian enzymes specifically degrade 8-oxo-dGTP to 8-oxo-dGMP, thereby preventing occurrence of transversion mutation. The gene encoding the human enzyme, designated MTH1 (for mutT homologue 1), maps to chromosome 7p22. These proteins may be responsible for genomic stability. |
| Links | |
| Keywords |
Bacterial Proteins/metabolism; DNA Repair Enzymes; Deoxyguanine Nucleotides/metabolism; Escherichia coli/genetics; Escherichia coli Proteins; Humans; Mutagenesis; Phosphoric Monoester Hydrolases/metabolism; Pyrophosphatases |
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