PMID:9133662
| Citation |
Connelly, JC and Leach, DR (1996) The sbcC and sbcD genes of Escherichia coli encode a nuclease involved in palindrome inviability and genetic recombination. Genes Cells 1:285-91 |
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| Abstract |
Long DNA palindromes have the potential to adopt hairpin or cruciform secondary structures that inhibit DNA replication. In Escherichia coli, this palindrome-mediated inviability results from the activity of the sbcC and sbcD genes, and genetic observations have suggested that they may encode a nuclease. Mutations in these genes also restore the defect in genetic recombination associated with recBC sbcB mutants. |
| Links | |
| Keywords |
Adenosine Triphosphate/metabolism; Bacterial Proteins/chemistry; Bacterial Proteins/genetics; Bacterial Proteins/isolation & purification; DNA, Bacterial/chemistry; DNA, Bacterial/genetics; DNA, Bacterial/metabolism; DNA, Single-Stranded/chemistry; DNA, Single-Stranded/metabolism; Deoxyribonucleases/chemistry; Deoxyribonucleases/genetics; Deoxyribonucleases/isolation & purification; Escherichia coli/enzymology; Escherichia coli/genetics; Escherichia coli Proteins; Exonucleases/chemistry; Exonucleases/genetics; Exonucleases/isolation & purification; Genes, Bacterial/physiology; Molecular Weight; Nucleic Acid Conformation; Recombination, Genetic |
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