PMID:9077455
| Citation |
Yokochi, T, Kato, J and Ikeda, H (1996) DNA nicking by Escherichia coli topoisomerase IV with a substitution mutation from tyrosine to histidine at the active site. Genes Cells 1:1069-75 |
|---|---|
| Abstract |
Escherichia coli topoisomerase IV is a type II topoisomerase composed of ParC and ParE subunits and plays a major role in the decatenation of replicated molecules. The reaction with type II topoisomerases involves the cutting through transesterification between an active-site tyrosine and a DNA phosphodiester bond and a rejoining of cleaved DNA. |
| Links | |
| Keywords |
Base Sequence; Binding Sites; DNA/metabolism; DNA Topoisomerases, Type II/chemistry; Escherichia coli/enzymology; Histidine/chemistry; Mutation; Tyrosine/chemistry |
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