PMID:9048484
| Citation |
Missiakas, D and Raina, S (1997) Protein misfolding in the cell envelope of Escherichia coli: new signaling pathways. Trends Biochem. Sci. 22:59-63 |
|---|---|
| Abstract |
Depending on their cellular localization, misfolded proteins in Escherichia coli trigger two different heat-shock responses. Cytoplasmic proteins induce the 'classical' heat-shock regulon transcribed by the E sigma 32 polymerase. By contrast, misfolding of proteins in the cell envelope induces the newly described E sigma E-dependent regulon. This implies that there is an inducible transduction machinery in the inner membrane. The response to protein misfolding in the cell envelope is a finely tuned system regulated by a cascade of phosphorylation and dephosphorylation reactions. |
| Links | |
| Keywords |
Bacterial Proteins/chemistry; Bacterial Proteins/metabolism; Cell Membrane/metabolism; Escherichia coli/metabolism; Hot Temperature; Membrane Proteins/chemistry; Membrane Proteins/metabolism; Protein Folding; Signal Transduction |
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