PMID:9032054
| Citation |
Kercher, MA, Lu, P and Lewis, M (1997) Lac repressor-operator complex. Curr. Opin. Struct. Biol. 7:76-85 |
|---|---|
| Abstract |
For many years the lac operon of Escherichia coli has been the paradigm for gene regulation. Recently, the structures of the lac repressor core bound to isopropyl-beta-D-1-thiogalactoside (IPTG), the intact apo lac repressor, the intact lac repressor complexes with IPTG and a 21-base-pair symmetric operator, and the refined headpiece of the repressor have been determined. These structures have provided a framework for understanding a wealth of biochemical and genetic information. An analysis of these structures, as well as a description of their function and a comparison to homologous proteins, is now possible. |
| Links | |
| Keywords |
Allosteric Regulation; Bacterial Proteins/metabolism; Binding Sites; Escherichia coli Proteins; Lac Operon; Lac Repressors; Protein Binding; Repressor Proteins/metabolism |
| edit table |
Significance
You can help EcoliWiki by summarizing why this paper is useful
Useful Materials and Methods
You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.
Annotations
<annotationlinks/>
EcoliWiki Links
Add links to pages that link here (e.g. gene, product, method pages)
References
See Help:References for how to manage references in EcoliWiki.