PMID:8871401

Citation	Rouault, TA and Klausner, RD (1996) Iron-sulfur clusters as biosensors of oxidants and iron. Trends Biochem. Sci. 21:174-7
Abstract	Iron-sulfur clusters are prosthetic groups commonly found in proteins that participate in oxidation-reduction reactions and catalysis. Here, we focus on two proteins that contain iron-sulfur clusters, the fumarate nitrate reduction (FNR) protein of Escherichia coli and mammalian iron-responsive-element-binding protein 1 (IRP1), both of which function as direct sensors of oxygen and iron levels. Assembly and disassembly of iron-sulfur clusters is the key to sensing in these proteins and we speculate that iron-sulfur clusters might be found in other regulatory proteins that sense levels of iron and/or oxygen.
Links	PubMed
Keywords	Bacterial Proteins/metabolism; Escherichia coli Proteins; Iron/metabolism; Iron Regulatory Protein 1; Iron-Regulatory Proteins; Iron-Sulfur Proteins/metabolism; Iron-Sulfur Proteins/physiology; Models, Biological; Oxidants/metabolism; RNA-Binding Proteins/metabolism; Signal Transduction; Transcription Factors/metabolism
edit table

Significance

You can help EcoliWiki by summarizing why this paper is useful

You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.

Add links to pages that link here (e.g. gene, product, method pages)

See Help:References for how to manage references in EcoliWiki.