PMID:8831954
| Citation |
Inada, T and Nakamura, Y (1996) Autogenous control of the suhB gene expression of Escherichia coli. Biochimie 78:209-12 |
|---|---|
| Abstract |
The suhB gene encodes a 29-kDa protein that possesses inositol monophosphate activity and its mutations suppress several temperature-sensitive mutations in Escherichia coli. We found that the suhB gene is autoregulated; suhB- mutant strains oversynthesized the suhB mRNA and suhB-lacZ gene/operon fusion products. Since the half-life of the suhB transcript in the suhB mutant was much greater than the half-life in the wildtype strain, the suhB protein is implicated in the control of gene expression by modulating mRNA turnover. |
| Links | |
| Keywords |
Escherichia coli/enzymology; Escherichia coli/genetics; Gene Expression Regulation, Bacterial/physiology; Genes, Bacterial/genetics; Homeostasis; Mutation; Phosphoric Monoester Hydrolases/genetics; RNA, Bacterial/metabolism; RNA, Messenger/metabolism; Recombinant Fusion Proteins/biosynthesis |
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