PMID:8807872

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Citation

Nelson, HC and Bestor, TH (1996) Base eversion and shuffling by DNA methyltransferases. Chem. Biol. 3:419-23

Abstract

The structures of two DNA cytosine methyltransferases reveal two novel methods of gaining access to the substrate cytosine residue, both of which involve eversion of the cytosine in a process that may require DNA bending. In one instance there is also widespread base shuffling and distortion of the DNA.

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Keywords

DNA Modification Methylases/chemistry; DNA Modification Methylases/metabolism; Models, Molecular

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