PMID:8805245
| Citation |
Tatusov, RL, Mushegian, AR, Bork, P, Brown, NP, Hayes, WS, Borodovsky, M, Rudd, KE and Koonin, EV (1996) Metabolism and evolution of Haemophilus influenzae deduced from a whole-genome comparison with Escherichia coli. Curr. Biol. 6:279-91 |
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| Abstract |
The 1.83 Megabase (Mb) sequence of the Haemophilus influenzae chromosome, the first completed genome sequence of a cellular life form, has been recently reported. Approximately 75 % of the 4.7 Mb genome sequence of Escherichia coli is also available. The life styles of the two bacteria are very different - H. influenzae is an obligate parasite that lives in human upper respiratory mucosa and can be cultivated only on rich media, whereas E. coli is a saprophyte that can grow on minimal media. A detailed comparison of the protein products encoded by these two genomes is expected to provide valuable insights into bacterial cell physiology and genome evolution. |
| Links | |
| Keywords |
Bacterial Proteins/chemistry; Bacterial Proteins/metabolism; Biological Evolution; Conserved Sequence; DNA, Bacterial; Escherichia coli/genetics; Genome, Bacterial; Haemophilus influenzae/genetics; Haemophilus influenzae/metabolism; Molecular Sequence Data |
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