PMID:8682804
| Citation |
Ferguson, GP, Chacko, AD, Lee, CH, Booth, IR and Lee, C (1996) The activity of the high-affinity K+ uptake system Kdp sensitizes cells of Escherichia coli to methylglyoxal. J. Bacteriol. 178:3957-61 |
|---|---|
| Abstract |
Expression of the Kdp system sensitizes cells to methylglyoxal (MG) whether this electrophile is added externally or is synthesized endogenously. The basis of this enhanced sensitivity is the maintenance of a higher cytoplasmic pH (pHi) in cells expressing Kdp. In such cells, MG elicits rapid cytoplasmic acidification via KefB and KefC, but the steady-state pHi attained is still too high to confer protection Lowering pHi further by incubation with acetate increases the sensitivity of cells to MG. |
| Links | |
| Keywords |
Adenosine Triphosphatases/metabolism; Antiporters/metabolism; Bacterial Proteins/metabolism; Carrier Proteins/metabolism; Cation Transport Proteins; Escherichia coli/drug effects; Escherichia coli/growth & development; Escherichia coli/metabolism; Escherichia coli Proteins; Hydrogen-Ion Concentration; Potassium/metabolism; Potassium Channels/metabolism; Potassium-Hydrogen Antiporters; Pyruvaldehyde/pharmacology |
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