PMID:8637901
| Citation |
Pratt, LA and Silhavy, TJ (1996) The response regulator SprE controls the stability of RpoS. Proc. Natl. Acad. Sci. U.S.A. 93:2488-92 |
|---|---|
| Abstract |
In Escherichia coli, the sigma factor, RpoS, is a central regulator in stationary-phase cells. We have identified a gene, sprE (stationary-phase regulator), as essential for the negative regulation of rpoS expression. SprE negatively regulates the rpoS gene product at the level of protein stability, perhaps in response to nutrient availability. The ability of SprE to destabilize RpoS is dependent on the ClpX/ClpP protease. Based on homology, SprE is a member of the response regulator family of proteins. SprE is the first response regulator identified that is implicated in the control of protein stability. Moreover, SprE is the first reported protein that appears to regulate rpoS in response to a specific environmental parameter. |
| Links | |
| Keywords |
Adenosine Triphosphatases/metabolism; Bacterial Outer Membrane Proteins/genetics; Bacterial Proteins/physiology; Cell Count; DNA-Binding Proteins; Endopeptidase Clp; Escherichia coli/genetics; Escherichia coli/growth & development; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Genes, Bacterial; Glucose/metabolism; Molecular Chaperones; Protein Binding; Serine Endopeptidases/metabolism; Sigma Factor/genetics; Sigma Factor/metabolism; Transcription Factors; Water-Electrolyte Balance |
| edit table |
Significance
You can help EcoliWiki by summarizing why this paper is useful
Useful Materials and Methods
You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.
Annotations
<annotationlinks/>
EcoliWiki Links
Add links to pages that link here (e.g. gene, product, method pages)
References
See Help:References for how to manage references in EcoliWiki.