PMID:8619610

Citation	Benov, L and Fridovich, I (1996) Functional significance of the Cu,ZnSOD in Escherichia coli. Arch. Biochem. Biophys. 327:249-53
Abstract	Diethyl dithiocarbamate (DDC) was used to inhibit the copper- and zinc- containing superoxide dismutase (Cu,ZnSOD) of Escherichia coli in order to expose its physiological function. DDC inhibited the aerobic growth of a sodA sodB mutant much more than it did the growth of a SOD-replete parental strain and this inhibitory effect was oxygen-dependent. The SOD mimic MnTMPyP markedly diminished the growth inhibitory effect of DDC. Transfer of the sodA sodB strain from anaerobic to aerobic conditions induced fumarase C, which is a member of the soxRS regulon. DDC augmented this induction. These results indicate that the Cu,ZnSOD provides a defense against oxidative stress, which is more important to the sodA sodB mutant than to its SOD-replete parental strain.
Links	PubMed Online version:10.1006/abbi.1996.0117
Keywords	Aerobiosis; Anaerobiosis; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Ditiocarb/pharmacology; Enzyme Induction; Escherichia coli/enzymology; Escherichia coli/genetics; Escherichia coli/growth & development; Fumarate Hydratase/biosynthesis; Genes, Bacterial; Kinetics; Species Specificity; Superoxide Dismutase/antagonists & inhibitors; Superoxide Dismutase/genetics; Superoxide Dismutase/metabolism
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