PMID:8577258
| Citation |
Georgellis, D, Sohlberg, B, Hartl, FU and von Gabain, A (1995) Identification of GroEL as a constituent of an mRNA-protection complex in Escherichia coli. Mol. Microbiol. 16:1259-68 |
|---|---|
| Abstract |
An RNA-binding activity has been identified in Escherichia coli that provides physical protection of RNA against ribonucleases in an ATP- and Mg(2+)-dependent manner. This binding activity is stimulated under growth conditions known to cause a decrease in the rate of mRNA decay. RNA protection is mediated by a protein complex that contains a modified form of the chaperonin GroEL as an indispensable constituent. These results suggest a new role for GroEL as an RNA chaperone. |
| Links | |
| Keywords |
Adenosine Diphosphate/pharmacology; Adenosine Triphosphate/pharmacology; Antibodies, Monoclonal/immunology; Blotting, Western; Chaperonin 60/isolation & purification; Chaperonin 60/metabolism; Cytidine Triphosphate/metabolism; Escherichia coli/metabolism; Molecular Chaperones/metabolism; Protein Folding; RNA, Messenger/metabolism; RNA-Binding Proteins/metabolism; Ribonucleases/metabolism |
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