PMID:8543068
| Citation |
Nguyen, CC and Saier, MH Jr (1995) Phylogenetic, structural and functional analyses of the LacI-GalR family of bacterial transcription factors. FEBS Lett. 377:98-102 |
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| Abstract |
Phylogenetic tree construction for 25 sequenced members of the LacI-GalR family (LGF) of transcription factors revealed that almost all branches are similar in length, radiating essentially from a single point. This observation suggests that most of these proteins arose by duplication events which occurred at a specific time in evolutionary history, and that further duplication events were rare. Analyses of the multiple alignment of the LGF proteins lead to suggestions regarding structure-function relationships and reveal that the helix-turn-helix DNA-binding motif of LGF proteins is similar in sequence to those of numerous non-homologous DNA-binding proteins. |
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| Keywords |
Amino Acid Sequence; Bacterial Proteins/chemistry; Bacterial Proteins/metabolism; Escherichia coli Proteins; Lac Repressors; Molecular Sequence Data; Phylogeny; Repressor Proteins/chemistry; Repressor Proteins/metabolism; Transcription Factors/chemistry; Transcription Factors/metabolism |
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