PMID:8521301
| Citation |
Sulavik, MC, Gambino, LF and Miller, PF (1995) The MarR repressor of the multiple antibiotic resistance (mar) operon in Escherichia coli: prototypic member of a family of bacterial regulatory proteins involved in sensing phenolic compounds. Mol. Med. 1:436-46 |
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| Abstract |
The marR gene of Escherichia coli encodes a repressor of the marRAB operon, a regulatory locus controlling multiple antibiotic resistance in this organism. Inactivation of marR results in increased expression of marA, which acts at several target genes in the cell leading to reduced antibiotic accumulation. Exposure of E. coli to sodium salicylate (SAL) induces marRAB operon transcription and antibiotic resistance. The mechanism by which SAL antagonizes MarR repressor activity is unclear. |
| Links | |
| Keywords |
Amino Acid Sequence; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Base Sequence; Drug Resistance, Microbial/genetics; Drug Resistance, Multiple/genetics; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Gene Library; Molecular Sequence Data; Operon/genetics; Phenols/metabolism; Repressor Proteins/genetics; Repressor Proteins/metabolism; Sequence Alignment |
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