PMID:8486346

Citation	Lundin, LG (1993) Evolution of the vertebrate genome as reflected in paralogous chromosomal regions in man and the house mouse. Genomics 16:1-19
Abstract	Gene constellations on several human chromosomes are interpreted as indications of large regional duplications that took place during evolution of the vertebrate genome. Four groups of paralogous chromosomal regions in man and the house mouse are suggested and are believed to be conserved remnants of the two or three rounds of tetraploidization that are likely to have occurred during evolution of the vertebrates. The phenomenon of differential silencing of genes is described. The importance of conservation of linkage of particular genes is discussed in relation to genetic regulation and cell differentiation.
Links	PubMed Online version:10.1006/geno.1993.1133
Keywords	Animals; Biological Evolution; Cell Differentiation/genetics; Chromosomes; Chromosomes, Human; Genetic Linkage; Genome; Genome, Human; Humans; Mice; Multigene Family; Polyploidy; Species Specificity
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