PMID:8468304
| Citation |
Sakumi, K, Igarashi, K, Sekiguchi, M and Ishihama, A (1993) The Ada protein is a class I transcription factor of Escherichia coli. J. Bacteriol. 175:2455-7 |
|---|---|
| Abstract |
The methylated Ada protein of Escherichia coli, a regulatory protein for the adaptive response, binds to a target DNA from positions -62 to -31 upstream of the ada gene and facilitates the binding of RNA polymerase to the promoter. Mutant RNA polymerases consisting of C-terminal-deleted alpha subunits are virtually inactive in response to activation by the Ada protein. Thus, we conclude that the Ada protein is a class I transcription factor which requires the C-terminal region of the RNA polymerase alpha subunit for transcription activation. |
| Links | |
| Keywords |
Bacterial Proteins/chemistry; Bacterial Proteins/metabolism; Bacterial Proteins/pharmacology; Binding Sites; DNA, Bacterial/metabolism; Escherichia coli/genetics; Escherichia coli Proteins; O(6)-Methylguanine-DNA Methyltransferase; Structure-Activity Relationship; Transcription Factors/metabolism; Transcription Factors/pharmacology; Transcription, Genetic |
| edit table |
Significance
You can help EcoliWiki by summarizing why this paper is useful
Useful Materials and Methods
You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.
Annotations
<annotationlinks/>
EcoliWiki Links
Add links to pages that link here (e.g. gene, product, method pages)
References
See Help:References for how to manage references in EcoliWiki.