PMID:8464078

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Citation

Kolstø, AB, Bork, P, Kvaløy, K, Lindback, T, Grønstadt, A, Kristensen, T and Sander, C (1993) Prokaryotic members of a new family of putative helicases with similarity to transcription activator SNF2. J. Mol. Biol. 230:684-8

Abstract

Cloning and sequence analysis of a new open reading frame from Bacillus cereus reveals the relationship to a recently identified family of putative eukaryotic transcription activators similar to the yeast SNF2 gene product. As a result of comparative analysis of sequence features conserved in all members of this family, a gene from a chilo iridescent virus, as well as a putative helicase from Escherichia coli (hepA), can also be grouped into this family. The unexpected presence of prokaryotic and viral sequences in the previously purely eukaryotic SNF2 family suggests a defined subgroup of DNA helicases present in all species, with specific function in transcription activation.

Links

PubMed Online version:10.1006/jmbi.1993.1185

Keywords

Adenosine Triphosphatases; Amino Acid Sequence; Animals; Bacillus cereus/genetics; Bacillus cereus/metabolism; DNA Helicases/genetics; DNA-Binding Proteins/genetics; Databases, Factual; Fungal Proteins/genetics; Genes, Fungal; Humans; Molecular Sequence Data; Multigene Family; Nuclear Proteins; Open Reading Frames; Phylogeny; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Trans-Activators/genetics; Transcription Factors/genetics

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