PMID:8440369
| Citation |
Drewke, C, Notheis, C, Hansen, U, Leistner, E, Hemscheidt, T, Hill, RE and Spenser, ID (1993) Growth response to 4-hydroxy-L-threonine of Escherichia coli mutants blocked in vitamin B6 biosynthesis. FEBS Lett. 318:125-8 |
|---|---|
| Abstract |
Mutants of Escherichia coli (pdx B and pdx C) which are blocked in the biosynthesis of pyridoxol (vitamin B6) showed a growth response to 4-hydroxy-L-threonine. This observation constitutes the first direct evidence in support of the view that 4-hydroxy-L-threonine is implicated in the biosynthesis of vitamin B6. 1-Aminopropan-2,3-diol, the decarboxylation product of 4-hydroxy-L-threonine, does not support the growth of these mutants. Deuterium from deuterium-labelled 1-aminopropan-2,3-diol was not incorporated into pyridoxol. |
| Links | |
| Keywords |
Escherichia coli/growth & development; Escherichia coli/metabolism; Pyridoxine/biosynthesis; Threonine/analogs & derivatives; Threonine/metabolism |
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