PMID:8438231
| Citation |
Marger, MD and Saier, MH Jr (1993) A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport. Trends Biochem. Sci. 18:13-20 |
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| Abstract |
Many transport proteins of bacteria and eukaryotes are thought to possess a common structural motif of 12 transmembrane-spanning alpha-helical segments. In this report we use statistical methods to establish that five families or clusters of these facilitators comprise a single superfamily. The five clusters include: (1) drug-resistance proteins, (2) sugar facilitators, (3) facilitators for Krebs cycle intermediates, (4) phosphate ester-phosphate antiporters and (5) a distinct group of oligosaccharide-H+ symporters. Over 50 transporters of bacteria, lower eukaryotes, plants and animals, and one putative bacterial transcriptional regulatory protein are members of this superfamily, which we term the 'major facilitator superfamily' (MFS). |
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| Keywords |
Amino Acid Sequence; Animals; Bacterial Proteins/genetics; Biological Transport, Active; Carrier Proteins/genetics; Genes, Regulator; Humans; Ion Transport; Molecular Sequence Data; Monosaccharide Transport Proteins/genetics; Repressor Proteins/genetics |
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