PMID:8430073

Citation	Mukherjee, A, Dai, K and Lutkenhaus, J (1993) Escherichia coli cell division protein FtsZ is a guanine nucleotide binding protein. Proc. Natl. Acad. Sci. U.S.A. 90:1053-7
Abstract	FtsZ is an essential cell division protein in Escherichia coli that forms a ring structure at the division site under cell cycle control. The dynamic nature of the FtsZ ring suggests possible similarities to eukaryotic filament forming proteins such as tubulin. In this study we have determined that FtsZ is a GTP/GDP binding protein with GTPase activity. A short segment of FtsZ is homologous to a segment in tubulin believed to be involved in the interaction between tubulin and guanine nucleotides. A lethal ftsZ mutation, ftsZ3 (Rsa), that leads to an amino acid alteration in this homologous segment decreased GTP binding and hydrolysis, suggesting that interaction with GTP is essential for ftsZ function.
Links	PubMed PMC45809
Keywords	Bacterial Proteins/isolation & purification; Bacterial Proteins/metabolism; Cell Division; Cytoskeletal Proteins; Escherichia coli/cytology; Escherichia coli/enzymology; Escherichia coli/metabolism; GTP Phosphohydrolases/metabolism; GTP-Binding Proteins/metabolism; Guanine Nucleotides/metabolism; Guanosine Diphosphate/metabolism; Guanosine Triphosphate/metabolism; Kinetics; Mutagenesis
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